WITHDRAWN: Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
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چکیده
منابع مشابه
Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles were developed with a pH-responsive PEG layer that detached prior to cell uptake. Docetaxel (DTX) was incorporated into the lipid core of the nanoparticles, wh...
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متن کاملDevelopment of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer
The aim of the research work was to chemically modify guar gum(GG) as a pH sensitive co-polymer and formulating intestinal targeting ESO nanoparticles (NPs) using the synthesized co-polymer. Poly acrylamide-grafted-guar gum (PAAm-g-GG) co-polymer was synthesized by free radical polymerization. Chemical modification of PAAm-g-GG by alkaline hydrolysis results in formation of a pH-sensitive co-po...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2015.11.059